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Dehkhoda et al

Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models

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The activities of 2-OGDDs are affected by the intracellular level of -KG, succinate, fumarate, or 2-HG

SCFAs inhibit pro-inflammatory cytokine (IL-6, IL-12) release from DCs via GPR109A and HDAC suppression, skewing T cell differentiation toward tolerance (Kleuskens et al., 2022)